Lucy Liu, 50
At 50 years old, Lucy Liu hasn’t let her age limit her. After her debut in 1991 on “Beverly Hills, 90210” the actress appeared on several television shows before starring in major films like “Shanghai Noon,” “Charlie’s Angels,” “Kill Bill Vol. 2” and voicing Viper for the “Kung Fu Panda” franchise. From 2012 through 2019, she played a gender swap version of Dr. Watson for “Elementary” which is now regarded as one of the best interpretations of the classic character.