T.R. Knight and Isaiah Washington
It was no secret that things got quite tense between T.R. Knight and Patrick Dempsey in the beginning of ER, and it wasn’t long before this altercation made it into the headlines. Taking the opportunity to come out publicly as gay, Knight saw no other way out of the situation. Unfortunately, this did not sit well with Isaiah Washington who made an insensitive and homophobic remark about Knight while backstage at the Golden Globe Awards, leading to the end of their friendship and Washington’s subsequent release from ER.