‘The Fantastic Four’ #1
While “Marvel Comics’ #1 is rarer and more valuable, it can be argued that “The Fantastic Four’ #1 ushered in the true Marvel Age of comics. A copy of this book sold for $300,000 in 2011, which is a steal considering it’s basically the first true comic in the ongoing adventures of the Marvel universe, and dramatically changed superhero storytelling forever upon its initial release.