Born This Way
The best example is JFK.
Born with one leg slightly shorter than the other, leading to his famously unstable back.
Football injury in college exacerbates back problems.
Injury during PT-109 incident in WW2 further worsens back.
Fast-forward to Dallas, Texas. November 22nd, 1963. The first shot that hit Kennedy in the back was survivable. He could have easily ducked out of the way after, but his back brace kept him upright, leaving his head completely exposed.
JFK could have been saved had his one dang leg been the same size as the other.
Story credit: Reddit / littlepoot